Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria chloroquine-resistant. The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Maculopathies and macular degeneration can occur from 3 months to several years of exposure to this drug and may be irreversible. RUN FROM THIS MEDICATION! Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Talk to your doctor about this risk. How Can I Lessen Skin Reactions? Patients should be strongly warned to keep these drugs out of the reach of children see OVERDOSAGE. Meats, poultry, fish, eggs, dried beans and peas, and tofu.
Check the labels on all your medicines because they may contain acetaminophen. Ask your pharmacist about the safe use of those products. This drug should be taken with a meal or a glass of milk. This effect usually results in a within 15 to 60 minutes. When traveling in an area at risk for malaria, use protective clothing, insect repellent, and bed nets. Remain indoors or in well-screened areas when possible. If you are taking this medication to prevent or treat malaria, use it for your current travel or condition only. Do not use it later to prevent or treat another infection unless told to do so by your doctor. A different medication may be necessary in those cases.
NO SYMPTOMS of eye problems until the eye went completely blind OVERNIGHT. If you ARE on this medication. AB1, AB2, AB3, etc. Hi, 48 African American female- I began taking the pill in Jan. 2007 -I had a bad finger flare. I had the pills since late December 2006 - afraid to take, due to the side affects. Motta M, Tincani A, Faden D et al. Follow-up of infants exposed to hydroxychloroquine given to mothers during pregnancy and lactation. J Perinatol.
They may also have withdrawal symptoms. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. NF. Keep out of the reach of children. Costedoat-Chalumeau N, Amoura Z, Aymard G et al. Evidence of transplacental passage of hydroxychloroquine in humans. Arthritis Rheum. Hydroxychloroquine sulfate tablets are indicated for the prophylaxis of malaria in geographic areas where chloroquine resistance is not reported. Symptoms of CMV retinitis. In early stages, CMV retinitis causes no symptoms. My skin appears to be sensative, every now and then I get red patches on my face and ear area and I can tell they are there because I feel warm, but then they fade away -strange. If your symptoms do not improve within a few days or a few weeks or months for arthritis or if they become worse, check with your doctor. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. COMPLETELY BLIND. Eye surgeon diagnosed RUPTURED RETINA. This medication may slow down a child's growth. The doctor may recommend temporarily stopping the medication from time to time to reduce this risk. Your doctor may want you to start taking this medicine 1 to 2 weeks before you travel to an area where there is a chance of getting malaria. This will help you to see how you react to the medicine. Also, it will allow time for your doctor to change to another medicine if you have a reaction to this medicine.
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. International experts indicate that hydroxychloroquine is acceptable during breastfeeding. Quinacrine or medicines that may harm the liver eg, acetaminophen, methotrexate because they may increase the risk of hydroxychloroquine's side effects. Ask your doctor or pharmacist if you have questions about whether any of your medicines may harm the liver. For lupus or rheumatoid arthritis, take this medication by mouth, usually once or twice daily or as directed. Your doctor may gradually increase your dose. Once you have been taking the medication for a while and your condition has improved, your doctor may instruct you to lower your dose until you find the dose that works best with the fewest side effects. Long-term studies in animals have not been conducted to evaluate the carcinogenic potential of hydroxychloroquine sulfate. Cimetidine can inhibit the metabolism of chloroquine, increasing its plasma level. Concomitant use of cimetidine should be avoided. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. BUT, I AM NOT EVEN CLOSE to being a doctor, AND I don't know how severe your Lupus is. But when my doc let me try I didn't have a weaning process I was on 200mg am and 200 pm. I'd rather see you get a second opinion, but I'm telling you what I know because we all do what we want to do in the end.
This product should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: intestinal blockage obstruction. What is hydroxychloroquine, and how does it work mechanism of action? Hydroxychloroquine sulfate prolongs the QT interval and should not be administered with other drugs that have the potential to induce cardiac arrhythmias. Also, there may be an increased risk of inducing ventricular arrhythmias if hydroxychloroquine sulfate is used concomitantly with other arrhythmogenic drugs. Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition. Protect from heat, direct light, and moisture. not store in the bathroom. Keep all drug products away from children and pets. If you have kidney problems, your doctor might suggest eating a low-salt diet.
Hydroxychloroquine sulfate tablets are not recommended for malaria prophylaxis in geographic areas where chloroquine resistance occurs. This medicine is used to prevent and to treat malaria and to treat some conditions such as liver disease caused by protozoa. It is also used in the treatment of arthritis to help relieve inflammation, swelling, stiffness, and joint pain and to help control the symptoms of lupus erythematosus lupus; SLE. The following adverse reactions have been identified during post-approval use of hydroxychloroquine sulfate or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. African-Americans and Hispanic Americans. Red blood cells become crescent-shaped because of a genetic defect. They break down rapidly, so oxygen does not get to the body's organs, causing anemia. Clinical studies of hydroxychloroquine sulfate did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. However, this drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection and it may be useful to monitor renal function. Costedoat-Chalumeau N, Amoura Z, Sebbough D et al. Electroretinograms of children born to mothers treated with hydroxychloroquine during pregnancy and breast-feeding: comment on the article by Costedoat-Chalumeau et al. Author reply. Arthritis Rheum. Its mechanism of action is unknown. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.
AIDS medications, NSAIDs non-steroidal anti-inflammatory drugs or seizure medications. Tell your doctor all medications you use. Plaquenil should be used only when prescribed during pregnancy. This medication is not recommended to treat rheumatoid arthritis during pregnancy. This medication passes into breast milk. Consult your doctor before breast-feeding. Hydroxychloroquine sulfate tablets are indicated for the treatment of chronic discoid lupus erythematosus and systemic lupus erythematosus in adults. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Hydroxychloroquine is active against the erythrocytic forms of chloroquine sensitive strains of Plasmodium falciparum, Plasmodium malariae, Plasmodium ovale, and Plasmodium vivax. Hydroxychloroquine is not active against the gametocytes and exoerythrocytic forms including the hypnozoite stage P. vivax and P. ovale of the Plasmodium parasites. Human pregnancies resulting in live births have been reported in the literature and no increase in the rate of birth defects has been demonstrated. Embryonic deaths and malformations of anophthalmia and microphthalmia in the offspring have been reported when pregnant rats received large doses of chloroquine. Myopathy may be reversible after therapy discontinuation, but recovery may take many months. Now down to 400mg daily. Gastro problems not so severe now. My SLE symptoms were minor Sjogren's symptoms primarily and Prednisone actually solved it after a month.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Lab tests, including complete blood cell counts and eye tests, may be performed while you use hydroxychloroquine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Exclusivity is the sole marketing rights granted by the FDA to a manufacturer upon the approval of a drug and may run simultaneously with a patent. Exclusivity periods can run from 180 days to seven years depending upon the circumstance of the exclusivity grant. Rash, pruritus, pigmentation disorders in skin and mucous membranes, hair color changes, alopecia. Dermatitis bullous eruptions including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms DRESS syndrome photosensitivity, dermatitis exfoliative, acute generalized exanthematous pustulosis AGEP. AGEP has to be distinguished from psoriasis, although hydroxychloroquine sulfate may precipitate attacks of psoriasis. It may be associated with pyrexia and hyperleukocytosis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. The opinions expressed in WebMD Communities are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. Communities are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Ask your pharmacist about using these products safely. The baseline exam should include: best corrected distance visual acuity BCVA an automated threshold visual field VF of the central 10 degrees with retesting if an abnormality is noted and spectral domain ocular coherence tomography SDOCT. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication. What are rheumatoid arthritis causes and risk factors? Combined use of methotrexate with hydroxychloroquine sulfate has not been studied and may increase the incidence of adverse effects. When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well. Decreased appetite, hypoglycemia, porphyria, weight decreased. An increased plasma cyclosporin level was reported when cyclosporin and hydroxychloroquine sulfate were coadministered. Keep this medicine out of the reach of children. Children are especially sensitive to the effects of hydroxychloroquine and overdose is especially dangerous in children. Taking as few as 3 or 4 tablets 250-mg strength of chloroquine has resulted in death in small children. Hydroxychloroquine is probably just as dangerous.
Where can people get additional information on rheumatoid arthritis? All medicines may cause side effects, but many people have no, or minor, side effects. You can also try rehabilitation services that can help you use the vision you have in a more effective way. FDA product labels and may differ in countries outside the USA. Every effort has been made to ensure that the information provided on this page is accurate, up-to-date and complete, but no guarantee is made to that effect. Drugs. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight. For malaria prevention, take this medication by mouth once a week on the same day of the week, or as directed by your doctor. Mark a calendar to help you remember. This drug is usually started 2 weeks before entering the area with malaria. Take it once weekly while in the area, and continue taking it for 4 to 8 weeks after leaving the area or as directed by your doctor. To treat malaria, follow your doctor's instructions. Infants exposed to hydroxychloroquine during breastfeeding receive only small amounts of the drug in breastmilk. In a small number of infants up to at least 1 year of age, careful follow-up found no adverse effects on growth, vision or hearing. When red blood cells are fragile and cannot withstand the routine stress of the circulatory system, they may rupture prematurely, causing hemolytic anemia. Hemolytic anemia can be present at birth or develop later. Sometimes there is no known cause. What is rheumatoid arthritis RA?
Lead exposure is toxic to the bone marrow, leading to fewer red blood cells. Lead poisoning occurs in adults from work-related exposure and in children who eat paint chips, for example. Improperly glazed pottery can also taint food and liquids with lead. The following interactions have been observed on treatment with the structurally related substance chloroquine phosphate, and therefore cannot be ruled out for hydroxychloroquine. Some forms of anemia -- like the mild anemia that develops during pregnancy -- are even considered normal. However, some types of anemia may present lifelong health problems. What Causes Anemia? Hydroxychloroquine sulfate prolongs the QT interval. Ventricular arrhythmias and torsades de pointes have been reported in patients taking hydroxychloroquine sulfate see OVERDOSAGE. Therefore, hydroxychloroquine sulfate should not be administered with other drugs that have the potential to prolong the QT interval see DRUG INTERACTIONS. The side effects include redness, bruising, breast pain, infection, weakness, and an increased risk of fractured ribs. Older adults also may have a greater risk of developing anemia because of poor diet and other medical conditions. There is no single blood test for diagnosing lupus. Systemic Lupus Erythematosis SLE is diagnosed using 11 criteria. IF you have 4 out of 11 it is likely you have lupus. Respiratory support and shock management should be instituted as necessary. However, it is unlikely that steady state had been reached at this time. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Retinopathy may progress even after the drug is discontinued. About FAERS: The FDA Adverse Event Reporting System FAERS is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS. The normal frequency of varies from once daily to 1 to 2 times weekly. Constipation is best treated by drinking plenty of fluids four to six 8-ounce glasses daily eating foods high in fiber, and regularly. Fitzgerald. As you get better, your will probably reduce the dose. Some people need long-term treatment with low-dose steroids; others can stop taking them altogether. Great support and practical tips can come from talking with other people with cancer. Ask your doctor or social worker how to find good support groups near you or online. Concomitant hydroxychloroquine sulfate and digoxin therapy may result in increased serum digoxin levels: serum digoxin levels should be closely monitored in patients receiving combined therapy. Americans. Women, young children, and people with chronic diseases are at increased risk of anemia. Zydus Pharmaceuticals USA Inc. Hydroxychloroquine sulfate should be administered with caution in patients having glucose-6-phosphate dehydrogenase G-6-PD deficiency. Hydroxychloroquine is available only with your doctor's prescription. This may sometimes be followed by a dose of 400 mg six to eight hours after the first dose, then 400 mg once a day on the second and third days. Following a single 200 mg oral dose of hydroxychloroquine sulfate to healthy males, the mean peak blood concentration of hydroxychloroquine was 129. If your symptoms do not improve or if they become worse, check with your doctor. Rabies vaccine because its effectiveness may be decreased by hydroxychloroquine. Vertigo, tinnitus, nystagmus, nerve deafness, deafness.
If objective improvement such as reduced joint swelling, increased mobility does not occur within 6 months, therapy should be discontinued. Common treatment methods don't change the progression of osteoarthritis. However, two nutritional supplements -- glucosamine and chondroitin sulfates -- are being studied to determine if they can relieve pain or perhaps slow the breakdown of cartilage, which is a significant part of osteoarthritis. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. What is the prognosis for patients with rheumatoid arthritis? PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using hydroxychloroquine while you are pregnant. Hydroxychloroquine is found in breast milk. If you are or will be breast-feeding while you use hydroxychloroquine, check with your doctor. Discuss any possible risks to your baby. It is recommended that hydroxychloroquine be discontinued if ocular toxicity is suspected and the patient should be closely observed given that retinal changes and visual disturbances may progress even after cessation of therapy. Cimaz R, Brucato A, Meregalli E et al. Electroretinograms of children born to mothers treated with hydroxychloroquine during pregnancy and breast-feeding: comment on the article by Costedoat-Chalumeau et al. Arthritis Rheum. This drug may make you dizzy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit beverages. Reference Listed Drug RLD is an approved drug product to which new generic versions are compared to show that they are bioequivalent. A drug company seeking approval to market a generic equivalent must refer to the Reference Listed Drug in its Abbreviated New Drug Application ANDA. By designating a single reference listed drug as the standard to which all generic versions must be shown to be bioequivalent, FDA hopes to avoid possible significant variations among generic drugs and their brand name counterpart. Gotestam Skorpen C, Hoeltzenbein M, Tincani A et al. The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis. Hydroxychloroquine sulfate tablets do not prevent relapses of P. vivax or P. ovale because it is not active against the hypnozoite forms of these parasites. BCVA, VF and SD-OCT. For individuals without significant risk factors, annual exams can usually be deferred until five years of treatment. Sammaritano LR, Bermas BL. Rheumatoid arthritis medications and lactation. Curr Opin Rheumatol. If you are currently using this medication, tell your doctor or pharmacist before starting hydroxychloroquine. Another group of investigators have reported numerous infants whose mother took hydroxychloroquine during pregnancy and were breastfed during maternal hydroxychloroquine use. An abstract reported 16 infants breastfed for 1 to 19 months and followed up at an average of 24 months range 1 to 86 months with no evidence of visual or hearing deficits. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
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The presence of other medical problems may affect the use of this medicine. Cissoko H, Rouger J, Zahr N, Darrouzain F, Jonville-Bera AP, Autret-Leca E. Breast milk concentrations of hydroxychloroquine. Fundam Clin Pharmacol. Learn how occupational and physical therapy can help ease arthritis pain.
What are the stages of rheumatoid arthritis? Rarely scotomatous vision or field defects may occur without obvious retinal change. Cellular levels of patients on daily hydroxychloroquine have been shown to be higher in mononuclear cells than polymorphonuclear leucocytes.
Check your pressure regularly and tell your doctor if the results are high. In many people, stress can trigger flares. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company. Do not keep outdated medicine or medicine no longer needed.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Use of hydroxychloroquine sulfate in patients with psoriasis may precipitate a severe attack of psoriasis. When used in patients with porphyria the condition may be exacerbated. The preparation should not be used in these conditions unless in the judgment of the physician the benefit to the patient outweighs the possible hazard. Immunosuppressive drugs. Because lupus is a disease caused by an overactive immune system, drugs that suppress the immune system can help relieve symptoms.